There are several factors that are at the origin of the obesity. Among the most important, we undoubtedly find metabolic factors and cellular factors. Obesity is a chronic disease characterized by excess fat and which in turn is translated into a weight gain.
Lately the way in which some alterations metabolic may have an influence on the development of obesity.
The preferential deviation of substrates energetic towards the synthesis and storage of triglycerides.
Increased efficiency in the degradation of carbohydrates, fatty acids and amino acids, and in storing additional energy in the form of triglycerides in adipose tissue.
Superior efficiency to perform the work physiological, where less energy is required and where the excess of it is transformed into triglycerides that are stored in the fat tissue.
Inhibition during mobilization of the Energy stored as triglycerides in adipose tissue.
All the cells fat they consist of a large central lipid droplet surrounded by a thin border of cytoplasm. Adipocytes store fat in amounts equivalent to 80% or 95% of their volume.
El cloth adipose it becomes larger when the size of existing cells increases, adding lipids or increasing the number of cells. Weight gain can be the result of hypertrophy, hyperplasia, or both.
The fat deposits they can be extended up to 1000 times by hypertrophy, a process that occurs at any time, as long as the adipocytes have sufficient site. The hyperplasia it takes place mainly as a part of the growth process during infancy and adolescence, but also in adulthood when the fat content of existing cells reaches the limit of their capacity.
If the weight is low, the size of the obesity decreases. The number of cells does not increase until the maximum size of these is reached. It also does not decrease with weight reduction. Prevention is decisive since once the fat and it remains, it is more difficult to lose it.