Kunezici eziningana ezisemvelaphi ye- obesidad. Phakathi kwezinto ezibaluleke kakhulu, ngokungangabazeki sithola izici zemetabolic kanye nezici zeselula. Ukukhuluphala ngokweqile kuyisifo esingelapheki esibonakala ngamafutha amaningi futhi naso esihunyushelwa ku- isisindo somzimba
Muva nje indlela abanye izinguquko umzimba kungaba nethonya ekuthuthukiseni ukukhuluphala.
Ukuphambuka okukhethwayo kwe- substrates unamandla maqondana nokwenziwa nokugcinwa kwama-triglycerides.
Ukwanda kokusebenza kahle ekunciphisweni kwe carbohydrate, okunamafutha acid kanye nama-amino acid, nasekugcinweni kwamandla angeziwe ngesimo se-triglycerides kuzicubu ze-adipose.
Ukusebenza kahle okuphezulu kokwenza i- umsebenzi ngokomzimba, lapho kudingeka amandla amancane nalapho okudlulela kuwo kuguqulwa kube ama-triglycerides agcinwa ezicutshini ezinamafutha.
Ukuvimbela ngesikhathi sokugqugquzela amandla igcinwe njenge-triglycerides kuzicubu ze-adipose.
I-Las amaseli amafutha aqukethe i-lipid droplet enkulu emaphakathi ezungezwe umngcele omncane we-cytoplasm. Ama-adipocyte agcina amafutha ngamanani alingana no-80% noma 95% wevolumu yawo.
El izicubu i-adipose iba nkulu lapho ubukhulu bamaseli akhona benyuka, bengeza ama-lipids noma bandise inani lamaseli. Ukuzuza kwesisindo kungaba ngumphumela we-hypertrophy, hyperplasia, noma kokubili.
I-Los idiphozi yamafutha zinganwetshwa kuze kube izikhathi eziyi-1000 yi-hypertrophy, inqubo eyenzeka nganoma yisiphi isikhathi, inqobo nje uma ama-adipocyte enesiza esanele. I- i-hyperplasia kwenzeka ikakhulukazi njengengxenye yenqubo yokukhula ngesikhathi sobuntwana nasebusheni, kepha futhi nasebudaleni lapho okuqukethwe okunamafutha kwamaseli akhona kufinyelela umkhawulo wamandla abo.
Uma isisindo siphansi, ubukhulu be- i-adiposis kuncipha. Inani lamaseli alinyuki kuze kufike usayizi omkhulu walezi. Futhi ayinciphisi ngokunciphisa isisindo. Ukuvimbela kunqume kusukela lapho i grasa futhi ihlala, kunzima kakhulu ukuyilahla.